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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mocos
Name: molybdenum cofactor sulfurase
Acc ID: CHEBI:2208
Term: purine-6-thiol
Definition: A thiol that is the tautomer of mercaptopurine.
Chemical ID: MESH:D015122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mocosdecreases oxidationISOMOCOS (Homo sapiens)6480464CTDMOCOS gene SNP results in decreased oxidation of MercaptopurinePMID:29935280
Mocosmultiple interactionsISOMOCOS (Homo sapiens)6480464CTD[MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in decreased chemical synthesis of 6-thiouric acid; [MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in decreased chemical synthesis of 6-thioxanthine; [MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in increased chemical synthesis of ThioguaninePMID:29935280
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