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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308374
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt3
Name: sirtuin 3
Acc ID: CHEBI:64022
Term: nebivolol
Definition: A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Chemical ID: MESH:D000068577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt3increases expressionISOSirt3 (Mus musculus)6480464CTDNebivolol results in increased expression of SIRT3 proteinPMID:23886954
Sirt3multiple interactionsISOSirt3 (Mus musculus)6480464CTD3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of SIRT3 protein]PMID:23886954
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