GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt3 | decreases expression | ISO | Sirt3 (Mus musculus) | 6480464 | CTD | Sodium Fluoride results in decreased expression of SIRT3 mRNA | PMID:37739047 | Sirt3 | multiple interactions | ISO | SIRT3 (Homo sapiens) | 6480464 | CTD | [Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of SIRT3 protein; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased activity of and results in increased acetylation of SOD2 protein]; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased activity of IDH2 protein]; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of ATP6 mRNA]; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of COX1 mRNA]; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of CYTB mRNA]; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of ND2 mRNA]; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of ND5 mRNA]; SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased acetylation of FOXO3 protein] | PMID:34780879 | Sirt3 | multiple interactions | ISO | Sirt3 (Mus musculus) | 6480464 | CTD | [Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of SIRT3 protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA] | PMID:34780879 PMID:37739047 | | ||||||||||||||||||||||
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