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GENE - TERM ANNOTATION REPORT

RGD ID: 1308360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trio
Name: trio Rho guanine nucleotide exchange factor
Acc ID: GO:0005085
Term: guanyl-nucleotide exchange factor activity
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Definition Source(s): GOC:kd, GOC:mah, PMID:23303910, PMID:27218782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TrioenablesIBAFB:FBgn0024277 or MGI:103263 or MGI:96932 or PANTHER:PTN000518111 or Mcf2l (Rattus norvegicus) or UniProtKB:O15068 or UniProtKB:O60229 or WB:WBGene000068051600115GO_CentralGO_REF:0000033

GO_REF:0000033
TrioenablesIEAUniProtKB-KW:KW-03441600115UniProtGO_REF:0000043

GO_REF:0000043
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