GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slc39a8 | affects response to substance | ISO | SLC39A8 (Homo sapiens) | 6480464 | CTD | SLC39A8 protein affects the susceptibility to Cisplatin | PMID:30342059 | Slc39a8 | increases response to substance | ISO | Slc39a8 (Mus musculus) | 6480464 | CTD | SLC39A8 protein results in increased susceptibility to Cisplatin | PMID:30342059 | Slc39a8 | multiple interactions | ISO | SLC39A8 (Homo sapiens) | 6480464 | CTD | [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the cleavage of CASP3 protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the cleavage of PARP1 protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the expression of BAK1 protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the expression of BAX protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the expression of BCL2 protein | PMID:30342059 | Slc39a8 | multiple interactions | ISO | Slc39a8 (Mus musculus) | 6480464 | CTD | [SLC39A8 protein results in increased susceptibility to Cisplatin] which results in decreased expression of BCL2 protein; [SLC39A8 protein results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein; [SLC39A8 protein results in increased susceptibility to Cisplatin] which results in increased expression of BAK1 protein | PMID:30342059 | |
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