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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308236
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc39a8
Name: solute carrier family 39 member 8
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc39a8affects response to substanceISOSLC39A8 (Homo sapiens)6480464CTDSLC39A8 protein affects the susceptibility to CisplatinPMID:30342059
Slc39a8increases response to substanceISOSlc39a8 (Mus musculus)6480464CTDSLC39A8 protein results in increased susceptibility to CisplatinPMID:30342059
Slc39a8multiple interactionsISOSLC39A8 (Homo sapiens)6480464CTD[SLC39A8 protein affects the susceptibility to Cisplatin] which affects the cleavage of CASP3 protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the cleavage of PARP1 protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the expression of BAK1 protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the expression of BAX protein; [SLC39A8 protein affects the susceptibility to Cisplatin] which affects the expression of BCL2 proteinPMID:30342059
Slc39a8multiple interactionsISOSlc39a8 (Mus musculus)6480464CTD[SLC39A8 protein results in increased susceptibility to Cisplatin] which results in decreased expression of BCL2 protein; [SLC39A8 protein results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein; [SLC39A8 protein results in increased susceptibility to Cisplatin] which results in increased expression of BAK1 proteinPMID:30342059
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