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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308166
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c79
Name: cytochrome P450, family 2, subfamily c, polypeptide 79
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c79increases expressionISOCYP2C8 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of CYP2C8 mRNAPMID:27153767 PMID:32588087
Cyp2c79multiple interactionsISOCYP2C8 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid inhibits the reaction [CYP2C8 protein results in increased hydroxylation of Paclitaxel]PMID:21964418
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