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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307751
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding transcription factor 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf2multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Glucose results in increased expression of SREBF2 protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]PMID:23647015
Srebf2multiple interactionsISOSREBF2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of SREBF2 protein]; Quercetin promotes the reaction [SREBF2 protein binds to PON1 promoter]; Quercetin results in increased metabolism of and affects the localization of SREBF2 proteinPMID:20728021 PMID:22388943 PMID:23647015
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