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GENE - TERM ANNOTATION REPORT

RGD ID: 1307376
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rpa1
Name: replication protein A1
Acc ID: GO:0006289
Term: nucleotide-excision repair
Definition: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
Definition Source(s): PMID:10197977
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rpa1involved_inISORPA1 (Homo sapiens)1624291RGD PMID:9430682

PMID:9430682
Rpa1involved_inIBAPANTHER:PTN000588618 or UniProtKB:P276941600115GO_CentralGO_REF:0000033

GO_REF:0000033
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