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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307261
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsdmd
Name: gasdermin D
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsdmdincreases cleavageISOGSDMD (Homo sapiens)6480464CTDGlucose results in increased cleavage of GSDMD proteinPMID:35607288
Gsdmdincreases expressionISOGSDMD (Homo sapiens)6480464CTDGlucose results in increased expression of GSDMD mRNA; Glucose results in increased expression of GSDMD proteinPMID:37473909
Gsdmdincreases expressionISOGsdmd (Mus musculus)6480464CTDGlucose results in increased expression of GSDMD mRNAPMID:34212273
Gsdmdmultiple interactionsISOGSDMD (Homo sapiens)6480464CTDloganin inhibits the reaction [Glucose results in increased expression of GSDMD mRNA]; loganin inhibits the reaction [Glucose results in increased expression of GSDMD protein]; MIR200C mRNA affects the reaction [Glucose results in increased cleavage of GSDMD protein]; SLC30A7 protein affects the reaction [MIR200C mRNA affects the reaction [Glucose results in increased cleavage of GSDMD protein]]PMID:35607288 PMID:37473909
Gsdmdmultiple interactionsISOGsdmd (Mus musculus)6480464CTDGlucose results in increased expression of and results in increased cleavage of GSDMD protein; GSDMD protein affects the reaction [Glucose results in increased secretion of IL18 protein]; GSDMD protein affects the reaction [Glucose results in increased secretion of IL1B protein]; Hirudins inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of GSDMD protein]; IRF2 protein affects the reaction [Glucose results in increased expression of and results in increased cleavage of GSDMD protein]; IRF2 protein affects the reaction [Glucose results in increased expression of GSDMD mRNA]PMID:34212273
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