GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gsdmd | multiple interactions | EXP | | 6480464 | CTD | [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein] | PMID:35962723 | Gsdmd | increases cleavage | ISO | GSDMD (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased cleavage of GSDMD protein | PMID:34791735 | Gsdmd | increases expression | ISO | Gsdmd (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of GSDMD protein | PMID:37379125 | Gsdmd | multiple interactions | ISO | GSDMD (Homo sapiens) | 6480464 | CTD | 2-chloro-5-nitrobenzanilide inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]] | PMID:33851234 PMID:34217685 PMID:34269108 PMID:34791735 | Gsdmd | multiple interactions | ISO | Gsdmd (Mus musculus) | 6480464 | CTD | [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein; [triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein]; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of GSDMD protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of GSDMD protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein] | PMID:34212273 PMID:36002070 PMID:36328986 PMID:37379125 | | ||||||||||||||||||||||
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