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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rnaseh2a
Name: ribonuclease H2, subunit A
Acc ID: CHEBI:64215
Term: 2,3-dimethoxynaphthalene-1,4-dione
Definition: A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Chemical ID: MESH:C063002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rnaseh2aincreases expressionISORGD:13163286480464CTD2, 3-dimethoxy-1, 4-naphthoquinone results in increased expression of RNASEH2A mRNA

PMID:17547211
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.