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GENE - TERM ANNOTATION REPORT

RGD ID: 1307242
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kat2a
Name: lysine acetyltransferase 2A
Acc ID: GO:0140672
Term: ATAC complex
Definition: A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation.
Definition Source(s): GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kat2alocated_inISOKAT2A (Homo sapiens)1624291RGD PMID:19936620

PMID:19936620
Kat2apart_ofISOKAT2A (Homo sapiens)1624291RGD PMID:18838386

PMID:18838386
Kat2apart_ofISOKat2a (Mus musculus)1624291RGD PMID:20562830

PMID:20562830
Kat2apart_ofIBAFB:FBgn0020388 or MGI:1343094 or MGI:1343101 or PANTHER:PTN001111731 or UniProtKB:Q92830 or UniProtKB:Q928311600115GO_CentralGO_REF:0000033

GO_REF:0000033
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