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GENE - TERM ANNOTATION REPORT

RGD ID: 1307189
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb2
Name: nuclear factor kappa B subunit 2
Acc ID: GO:0038061
Term: non-canonical NF-kappaB signal transduction
Definition: An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).
Definition Source(s): GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb2involved_inISONfkb2 (Mus musculus)1624291RGD PMID:23583643

PMID:23583643
Nfkb2involved_inIBAMGI:103289 or MGI:1099800 or PANTHER:PTN000652441 or UniProtKB:P19838 or UniProtKB:Q042061600115GO_CentralGO_REF:0000033

GO_REF:0000033
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