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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307148
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col4a1
Name: collagen type IV alpha 1 chain
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col4a1increases expressionISOCOL4A1 (Homo sapiens)6480464CTDParaquat results in increased expression of COL4A1 mRNAPMID:34681664
Col4a1increases expressionISOCol4a1 (Mus musculus)6480464CTDParaquat results in increased expression of COL4A1 mRNAPMID:21463325 PMID:27375216 PMID:29273418
Col4a1multiple interactionsISOCol4a1 (Mus musculus)6480464CTDpirfenidone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]; thymoquinone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]PMID:27375216 PMID:29273418
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