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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp73
Name: tumor protein p73
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp73affects response to substanceISOTP73 (Homo sapiens)6480464CTDTP73 protein affects the susceptibility to FluorouracilPMID:18714155
Tp73multiple interactionsISOTP73 (Homo sapiens)6480464CTDTP73 protein promotes the reaction [Fluorouracil results in increased expression of GRAMD4 mRNA]PMID:21127500
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