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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307040
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k4multiple interactionsISOMAP2K4 (Homo sapiens)150429751RGDN-acetyl-L-cysteine inhibits the reaction [Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix] 
Map2k4multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]PMID:18703135 PMID:22085843
Map2k4multiple interactionsISOMAP2K4 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]PMID:18703135
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