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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307012
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Papss2
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Papss2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of PAPSS2 mRNAPMID:26496021
Papss2affects expressionISOPAPSS2 (Homo sapiens)6480464CTDEstradiol affects the expression of PAPSS2 mRNAPMID:14699072
Papss2decreases expressionISOPAPSS2 (Homo sapiens)6480464CTDEstradiol results in decreased expression of PAPSS2 mRNAPMID:24758408
Papss2increases expressionISOPAPSS2 (Homo sapiens)6480464CTDEstradiol results in increased expression of PAPSS2 mRNAPMID:19619570 PMID:31614463
Papss2multiple interactionsISOPAPSS2 (Homo sapiens)6480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of PAPSS2 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of PAPSS2 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PAPSS2 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of PAPSS2 mRNA; EGF protein inhibits the reaction [Estradiol results in decreased expression of PAPSS2 mRNA]PMID:19619570 PMID:20404318 PMID:20660070 PMID:24758408 PMID:30165855
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