GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rhobtb1 | affects methylation | ISO | RHOBTB1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of RHOBTB1 promoter | PMID:27901495 | Rhobtb1 | decreases expression | ISO | RHOBTB1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of RHOBTB1 mRNA | PMID:20064835 PMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291 | Rhobtb1 | decreases expression | ISO | Rhobtb1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of RHOBTB1 mRNA | PMID:19770486 PMID:21715664 | Rhobtb1 | decreases methylation | ISO | Rhobtb1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of RHOBTB1 5' UTR; Benzo(a)pyrene results in decreased methylation of RHOBTB1 exon; Benzo(a)pyrene results in decreased methylation of RHOBTB1 intron | PMID:27901495 | Rhobtb1 | increases mutagenesis | ISO | RHOBTB1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased mutagenesis of RHOBTB1 gene | PMID:25435355 | |
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