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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306701
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc39a4
Name: solute carrier family 39 member 4
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc39a4affects expressionISOSLC39A4 (Homo sapiens)6480464CTDZinc affects the expression of SLC39A4 proteinPMID:20479680
Slc39a4affects expressionISOSlc39a4 (Mus musculus)6480464CTDZinc affects the expression of SLC39A4 mRNAPMID:16682017
Slc39a4affects localizationISOSlc39a4 (Mus musculus)6480464CTDZinc affects the localization of SLC39A4 protein; Zinc deficiency affects the localization of SLC39A4 proteinPMID:12801924 PMID:14709598 PMID:15358787
Slc39a4decreases expressionISOSLC39A4 (Homo sapiens)6480464CTDZinc results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 proteinPMID:15753530 PMID:17202136
Slc39a4decreases expressionISOSlc39a4 (Mus musculus)6480464CTDZinc deficiency results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 proteinPMID:12514265 PMID:12801924 PMID:17202136 PMID:18020946
Slc39a4increases expressionISOSlc39a4 (Mus musculus)6480464CTDZinc deficiency results in increased expression of SLC39A4 mRNA; Zinc deficiency results in increased expression of SLC39A4 proteinPMID:12801924 PMID:15358787 PMID:18020946
Slc39a4increases response to substanceISOSlc39a4 (Mus musculus)6480464CTDSLC39A4 gene mutant form results in increased susceptibility to Zinc deficiencyPMID:17483098
Slc39a4increases transportISOSLC39A4 (Homo sapiens)6480464CTDSLC39A4 protein results in increased transport of ZincPMID:18326752
Slc39a4increases uptakeISOSLC39A4 (Homo sapiens)6480464CTDSLC39A4 protein results in increased uptake of ZincPMID:17202136
Slc39a4increases uptakeISOSlc39a4 (Mus musculus)6480464CTDSLC39A4 protein results in increased uptake of ZincPMID:12801924 PMID:14709598 PMID:15322118
Slc39a4multiple interactionsISOSLC39A4 (Homo sapiens)6480464CTDAmmonium Chloride inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; methyl-beta-cyclodextrin inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; Sucrose inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; Zinc results in increased ubiquitination of and results in increased degradation of SLC39A4 proteinPMID:17202136
Slc39a4multiple interactionsISOSlc39a4 (Mus musculus)6480464CTDCycloheximide inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Cycloheximide inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA]; Zinc affects the localization of and results in increased degradation of SLC39A4 protein; Zinc deficiency results in increased expression of and results in increased stability of SLC39A4 mRNA; Zinc inhibits the reaction [Zinc deficiency results in increased expression of and results in increased stability of SLC39A4 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 protein]PMID:12801924 PMID:18020946
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