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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306695
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pltp
Name: phospholipid transfer protein
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pltpaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of PLTP mRNAPMID:34747641
Pltpincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of PLTP mRNAPMID:33387578
Pltpdecreases expressionISOPltp (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PLTP mRNAPMID:19770486 PMID:28922406 PMID:33956508
Pltpmultiple interactionsISOPltp (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of PLTP mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]PMID:16054899 PMID:28433925
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