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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Larp1
Name: La ribonucleoprotein 1, translational regulator
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases response to substanceISORGD:16036866480464CTDLARP1 protein results in increased susceptibility to Sirolimus

PMID:25940091
multiple interactionsISORGD:16036866480464CTDLARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPL32 protein], LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPS20 protein], LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPS6 protein], Sirolimus inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein], Sirolimus promotes the reaction [LARP1 protein binds to PABPC1 mRNA], Sirolimus promotes the reaction [LARP1 protein binds to RPL32 mRNA], Sirolimus promotes the reaction [LARP1 protein binds to RPS20 mRNA], Sirolimus promotes the reaction [LARP1 protein binds to RPS6 mRNA]

PMID:25940091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.