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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chukincreases phosphorylationEXP 6480464CTDLipopolysaccharides results in increased phosphorylation of CHUK proteinPMID:15466358 PMID:21893401
Chukmultiple interactionsEXP 6480464CTDwuzi yanzong analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]PMID:21893401
Chukincreases activityISOCHUK (Homo sapiens)6480464CTDLipopolysaccharides results in increased activity of CHUK proteinPMID:11739238
Chukincreases activityISOChuk (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of CHUK proteinPMID:10820281
Chukincreases phosphorylationISOCHUK (Homo sapiens)6480464CTDLipopolysaccharides results in increased phosphorylation of CHUK proteinPMID:18789402 PMID:20715105
Chukincreases phosphorylationISOChuk (Mus musculus)6480464CTDLipopolysaccharides results in increased phosphorylation of CHUK proteinPMID:18789402 PMID:21048310 PMID:22118570 PMID:23535395 PMID:30769083 PMID:31850465 PMID:37390879
Chukmultiple interactionsISOCHUK (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein]; gingerenone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; glucosamine 6-O-sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of CHUK protein]; HNRNPD protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein]; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein; Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein]; NOX1 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]PMID:11739238 PMID:17067557 PMID:18789402 PMID:20715105 PMID:21135123 PMID:21877189 PMID:28513976
Chukmultiple interactionsISOChuk (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; 4-hydroxymercuribenzoate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; [Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of CHUK protein; arctigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; arctiin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; Aurothioglucose inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; cobaltous chloride inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; erythraline inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein]; Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of CHUK protein]; gold chloride inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; helenalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; Lipopolysaccharides results in increased activity of and results in increased phosphorylation of CHUK protein; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; matairesinol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CHUK protein]; Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; scutellarein tetramethyl ether inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]; sodium bichromate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]; Zinc Sulfate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]PMID:10820281 PMID:16171798 PMID:17067557 PMID:17322126 PMID:18789402 PMID:21048310 PMID:21276822 PMID:22118570 PMID:23535395 PMID:23902980 PMID:30769083 PMID:31850465 PMID:37390879
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