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RGD ID: 1306605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Acc ID: GO:0033781
Term: cholesterol 24-hydroxylase activity
Definition: Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
Definition Source(s): EC:, RHEA:22716
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp46a1 ISORGD:13153141624291RGD (PMID:14640697), (PMID:18621681), (PMID:25017465)

PMID:14640697, PMID:18621681, PMID:25017465
Cyp46a1 ISORGD:13153151624291RGD (MGI:MGI:1339884, PMID:10377398)

MGI:MGI:1339884, PMID:10377398
Cyp46a1 IBAPANTHER:PTN001210149, UniProtKB:Q9Y6A213792537GO_CentralPMID:21873635

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.