Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp46a1affects expressionISORGD:13153146480464CTDValproic Acid affects the expression of CYP46A1 mRNA

PMID:25979313
Cyp46a1increases expressionISORGD:13153146480464CTDValproic Acid results in increased expression of CYP46A1 mRNA

PMID:23179753, PMID:26272509, PMID:27188386
Cyp46a1increases expressionISORGD:13153156480464CTDValproic Acid results in increased expression of CYP46A1 mRNA

PMID:21427059, PMID:24489787
Cyp46a1multiple interactionsISORGD:13153146480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP46A1 mRNA

PMID:27188386
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.