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RGD ID: 1306605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp46a1affects expressionISORGD:13153146480464CTDValproic Acid affects the expression of CYP46A1 mRNA

Cyp46a1increases expressionISORGD:13153146480464CTDValproic Acid results in increased expression of CYP46A1 mRNA

PMID:23179753, PMID:26272509, PMID:27188386
Cyp46a1increases expressionISORGD:13153156480464CTDValproic Acid results in increased expression of CYP46A1 mRNA

PMID:21427059, PMID:24489787
Cyp46a1multiple interactionsISORGD:13153146480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP46A1 mRNA

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.