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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306479
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4b
Name: eukaryotic translation initiation factor 4B
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4baffects localizationISOEIF4B (Homo sapiens)6480464CTDsodium arsenite affects the localization of EIF4B proteinPMID:16951406
Eif4bincreases expressionISOEif4b (Mus musculus)6480464CTDsodium arsenite results in increased expression of EIF4B mRNA; sodium arsenite results in increased expression of EIF4B proteinPMID:21268130
Eif4bincreases phosphorylationISOEif4b (Mus musculus)6480464CTDsodium arsenite results in increased phosphorylation of EIF4B proteinPMID:21268130
Eif4bincreases response to substanceISOEif4b (Mus musculus)6480464CTDEIF4B protein results in increased susceptibility to sodium arsenitePMID:21268130
Eif4bmultiple interactionsISOEIF4B (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of and results in increased activity of EIF4B proteinPMID:30528433
Eif4bmultiple interactionsISOEif4b (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF4B protein]; EIF4B protein promotes the reaction [sodium arsenite results in increased expression of MYC mRNA]; Sirolimus inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF4B protein]PMID:21268130
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