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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306361
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ube3a
Name: ubiquitin protein ligase E3A
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ube3adecreases expressionISOUBE3A (Homo sapiens)6480464CTDNicotine results in decreased expression of UBE3A mRNAPMID:12588870
Ube3amultiple interactionsISOUBE3A (Homo sapiens)6480464CTDMecamylamine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]; Nicotine inhibits the reaction [alpha-cobratoxin results in decreased expression of UBE3A mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]PMID:12588870
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