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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306160
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrp1b
Name: LDL receptor related protein 1B
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp1baffects methylationISOLRP1B (Homo sapiens)6480464CTDAflatoxin B1 affects the methylation of LRP1B intronPMID:30157460
Lrp1bdecreases expressionISOLRP1B (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of LRP1B mRNAPMID:22100608 PMID:31555880 PMID:32234424
Lrp1bdecreases methylationISOLRP1B (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of LRP1B promoterPMID:31555880
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