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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306078
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2s1
Name: cytochrome P450, family 2, subfamily s, polypeptide 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2s1decreases expressionISOCYP2S1 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of CYP2S1 mRNA; Dexamethasone results in decreased expression of CYP2S1 proteinPMID:22155357
Cyp2s1multiple interactionsISOCYP2S1 (Homo sapiens)6480464CTDNR3C1 protein promotes the reaction [Dexamethasone results in decreased expression of CYP2S1 mRNA]; NR3C1 protein promotes the reaction [Dexamethasone results in decreased expression of CYP2S1 protein]; trichostatin A inhibits the reaction [Dexamethasone results in decreased expression of CYP2S1 mRNA]PMID:22155357
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