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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306035
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Yap1
Name: Yes1 associated transcriptional regulator
Acc ID: CHEBI:36386
Term: dichloroacetic acid
Definition: An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.
Chemical ID: MESH:D003999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Yap1affects localizationISOYAP1 (Homo sapiens)6480464CTDDichloroacetic Acid affects the localization of YAP1 proteinPMID:33405312
Yap1multiple interactionsISOYAP1 (Homo sapiens)6480464CTDYAP1 protein mutant form inhibits the reaction [Dichloroacetic Acid results in decreased expression of EPCAM mRNA]; YAP1 protein mutant form inhibits the reaction [Dichloroacetic Acid results in decreased expression of EPCAM protein]; YAP1 protein mutant form inhibits the reaction [Dichloroacetic Acid results in decreased expression of KLF4 mRNA]; YAP1 protein mutant form inhibits the reaction [Dichloroacetic Acid results in decreased expression of KLF4 protein]; YAP1 protein mutant form inhibits the reaction [Dichloroacetic Acid results in decreased expression of PROM1 mRNA]; YAP1 protein mutant form inhibits the reaction [Dichloroacetic Acid results in decreased expression of PROM1 protein]PMID:33405312
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