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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306035
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Yap1
Name: Yes1 associated transcriptional regulator
Acc ID: CHEBI:10136
Term: gingerol
Definition: A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.
Chemical ID: MESH:C007845
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Yap1affects localizationISOYAP1 (Homo sapiens)6480464CTDgingerol affects the localization of YAP1 proteinPMID:32926756
Yap1multiple interactionsISOYAP1 (Homo sapiens)6480464CTD[gingerol co-treated with YAP1 protein] results in increased phosphorylation of YAP1 protein; gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]; gingerol results in decreased expression of and results in increased phosphorylation of YAP1 proteinPMID:32926756
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