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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305967
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cux2
Name: cut-like homeobox 2
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CUX2 mRNA, [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA, Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA]

PMID:22129741
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.