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GENE - TERM ANNOTATION REPORT

RGD ID: 1305932
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nccrp1
Name: NCCRP1, F-box associated domain containing
Acc ID: GO:0030433
Term: ubiquitin-dependent ERAD pathway
Definition: The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Definition Source(s): GOC:mah, GOC:rb, PMID:14607247, PMID:19520858
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAMGI:MGI:1354743, MGI:MGI:2446216, PANTHER:PTN00025236913792537GO_CentralPMID:21873635

 
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.