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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305887
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tubb6
Name: tubulin, beta 6 class V
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tubb6decreases expressionISOTUBB6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of TUBB6 mRNAPMID:31255691
Tubb6decreases expressionISOTubb6 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of TUBB6 mRNAPMID:20504355
Tubb6decreases methylationISOTUBB6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of TUBB6 promoterPMID:27901495
Tubb6increases expressionISOTUBB6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of TUBB6 mRNAPMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170 PMID:26238291 PMID:32234424
Tubb6increases expressionISOTubb6 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of TUBB6 mRNAPMID:22228805
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