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GENE - TERM ANNOTATION REPORT

RGD ID: 1305849
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rin3
Name: Ras and Rab interactor 3
Acc ID: GO:0005085
Term: guanyl-nucleotide exchange factor activity
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Definition Source(s): GOC:kd, GOC:mah, PMID:23303910, PMID:27218782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rin3enablesISORIN3 (Homo sapiens)1624291RGD PMID:21586568 PMID:23185384

PMID:21586568 PMID:23185384
Rin3enablesIBAFB:FBgn0262937 or MGI:1913941 or MGI:2444024 or PANTHER:PTN000559490 or SGD:S000004563 or SGD:S000005991 or TAIR:locus:2092211 or UniProtKB:Q10NQ3 or UniProtKB:Q14C86 or UniProtKB:Q8TB24 or UniProtKB:Q9UJ411600115GO_CentralGO_REF:0000033

GO_REF:0000033
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