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GENE - TERM ANNOTATION REPORT

RGD ID: 1305760
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xpc
Name: XPC complex subunit, DNA damage recognition and repair factor
Acc ID: GO:0006289
Term: nucleotide-excision repair
Definition: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
Definition Source(s): PMID:10197977
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xpcacts_upstream_of_or_withinISOXpc (Mus musculus)1624291RGDMGI:1859840 MGI:1931883 PMID:12815074 PMID:17049932 PMID:19615386 PMID:9067411

PMID:12815074 PMID:17049932 PMID:19615386 PMID:9067411
Xpcinvolved_inISOXPC (Homo sapiens)1624291RGD PMID:11259578 PMID:19941824 PMID:8168482 PMID:9734359

PMID:11259578 PMID:19941824 PMID:8168482 PMID:9734359
Xpcinvolved_inISOXpc (Mus musculus)1624291RGD PMID:22431748

PMID:22431748
Xpcinvolved_inIBAMGI:103557 or PANTHER:PTN000253194 or PomBase:SPAC12B10.12c or PomBase:SPCC4G3.10c or SGD:S000000964 or SGD:S000002722 or TAIR:locus:2174160 or UniProtKB:Q018311600115GO_CentralGO_REF:0000033

GO_REF:0000033
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