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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305742
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tia1
Name: TIA1 cytotoxic granule-associated RNA binding protein
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tia1affects localizationEXP 6480464CTDsodium arsenite affects the localization of TIA1 proteinPMID:19171178
Tia1multiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [sodium arsenite affects the localization of TIA1 protein]; sodium arsenite promotes the reaction [TIA1 protein binds to ELAV1 protein binds to DYNLL2 protein]; TIA1 mutant form inhibits the reaction [sodium arsenite results in decreased susceptibility to [TNF protein co-treated with Cycloheximide]]PMID:19171178 PMID:22555848
Tia1affects localizationISOTIA1 (Homo sapiens)6480464CTDsodium arsenite affects the localization of TIA1 proteinPMID:16951406
Tia1decreases expressionISOTIA1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of TIA1 mRNAPMID:28595984 PMID:34032870
Tia1multiple interactionsISOTIA1 (Homo sapiens)6480464CTDEIF2A protein mutant form inhibits the reaction [sodium arsenite affects the localization of TIA1 protein]; sodium arsenite promotes the reaction [AGO2 protein binds to TIA1 protein]PMID:16951406 PMID:30404558
Tia1multiple interactionsISOTia1 (Mus musculus)6480464CTDsodium arsenite promotes the reaction [ELAVL1 protein binds to TIA1 protein]; sodium arsenite promotes the reaction [TARDBP protein binds to TIA1 protein]; sodium arsenite promotes the reaction [TIA1 protein binds to and affects the localization of GRIA2 mRNA]; sodium arsenite promotes the reaction [TIA1 protein binds to and affects the localization of YBX1 protein]PMID:19765185 PMID:24231679
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