GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ppm1d | affects activity | ISO | PPM1D (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the activity of PPM1D | PMID:18482988 | Ppm1d | decreases expression | ISO | PPM1D (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of PPM1D protein | PMID:21175813 | Ppm1d | increases expression | ISO | Ppm1d (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of PPM1D mRNA | PMID:29095437 | Ppm1d | multiple interactions | ISO | PPM1D (Homo sapiens) | 6480464 | CTD | MIR29A protein affects the reaction [Arsenic Trioxide results in decreased expression of PPM1D protein]; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein]; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] | PMID:18482988 PMID:21175813 | Ppm1d | multiple interactions | ISO | Ppm1d (Mus musculus) | 6480464 | CTD | Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA] | PMID:29095437 | |
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