Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppm1d
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1D
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppm1daffects activityISOPPM1D (Homo sapiens)6480464CTDArsenic Trioxide affects the activity of PPM1DPMID:18482988
Ppm1ddecreases expressionISOPPM1D (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of PPM1D proteinPMID:21175813
Ppm1dincreases expressionISOPpm1d (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of PPM1D mRNAPMID:29095437
Ppm1dmultiple interactionsISOPPM1D (Homo sapiens)6480464CTDMIR29A protein affects the reaction [Arsenic Trioxide results in decreased expression of PPM1D protein]; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein]; PPM1D mutant form promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]PMID:18482988 PMID:21175813
Ppm1dmultiple interactionsISOPpm1d (Mus musculus)6480464CTDMetformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA]PMID:29095437
Go Back to source page   Continue to Ontology report