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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305446
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trrap
Name: transformation/transcription domain-associated protein
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trrapaffects expressionEXP 6480464CTDbisphenol A affects the expression of TRRAP mRNAPMID:25181051 PMID:30816183
Trrapdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TRRAP mRNAPMID:26982218
Trrapdecreases expressionISOTRRAP (Homo sapiens)6480464CTDbisphenol A results in decreased expression of TRRAP proteinPMID:33376534
Trrapdecreases methylationISOTRRAP (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of TRRAP genePMID:31601247
Trrapincreases expressionISOTrrap (Mus musculus)6480464CTDbisphenol A results in increased expression of TRRAP mRNAPMID:33221593
Trrapmultiple interactionsISOTRRAP (Homo sapiens)6480464CTD[bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRRAP protein modified form]; [ginger extract results in increased abundance of Oils, Volatile] inhibits the reaction [bisphenol A results in decreased expression of TRRAP protein]; bisphenol A inhibits the reaction [ESR1 protein binds to TRRAP protein]PMID:28751236 PMID:29389661 PMID:33376534
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