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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305388
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Josd1
Name: Josephin domain containing 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Josd1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of JOSD1 mRNAPMID:33387578
Josd1affects expressionISOJosd1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of JOSD1 mRNAPMID:18343893 PMID:21570461
Josd1increases expressionISOJosd1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of JOSD1 mRNAPMID:15328365 PMID:21889950 PMID:23994337 PMID:25975270
Josd1multiple interactionsISOJosd1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of JOSD1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of JOSD1 mRNAPMID:16214954 PMID:25975270
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