GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mdm2 | increases expression | EXP | | 6480464 | CTD | Ursodeoxycholic Acid results in increased expression of MDM2 mRNA | PMID:15885361 | Mdm2 | multiple interactions | EXP | | 6480464 | CTD | [Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein; MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid affects the localization of TP53 protein]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]; Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein] | PMID:14514686 PMID:15222754 PMID:17881359 | Mdm2 | multiple interactions | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein] | PMID:20807506 | | ||||||||||||||||||||||
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