GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mdm2 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of MDM2 mRNA | PMID:12187937 PMID:27255381 PMID:34713381 | Mdm2 | affects expression | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the expression of MDM2 mRNA | PMID:25529476 PMID:29803840 | Mdm2 | affects expression | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | Doxorubicin affects the expression of MDM2 mRNA | PMID:29653124 | Mdm2 | decreases response to substance | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | MDM2 protein results in decreased susceptibility to Doxorubicin | PMID:26317544 | Mdm2 | increases expression | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of MDM2 mRNA; Doxorubicin results in increased expression of MDM2 protein | PMID:14665630 PMID:17653088 PMID:17959036 PMID:19074854 PMID:19560264 PMID:26317544 | Mdm2 | increases expression | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of MDM2 mRNA | PMID:14766674 PMID:16949053 PMID:34713381 | Mdm2 | increases phosphorylation | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MDM2 protein | PMID:17935137 | Mdm2 | multiple interactions | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Doxorubicin inhibits the reaction [TP53 protein binds to MDM2 protein]; Doxorubicin results in increased activity of and results in increased expression of MDM2 protein; IFNA1 protein promotes the reaction [Doxorubicin results in increased expression of MDM2 protein]; MDM2 protein inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]; MDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]; SETD7 mutant form promotes the reaction [Doxorubicin results in increased expression of MDM2 mRNA]; SETD7 mutant form promotes the reaction [Doxorubicin results in increased expression of MDM2 protein]; TP53 affects the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein] | PMID:17935137 PMID:17959036 PMID:19351845 PMID:19714248 PMID:21624110 PMID:26317544 | Mdm2 | multiple interactions | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA] | PMID:14766674 | | ||||||||||||||||||||||
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