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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305322
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map4k4affects splicingEXP 6480464CTDValproic Acid affects the splicing of MAP4K4 mRNAPMID:29427782
Map4k4affects expressionISOMAP4K4 (Homo sapiens)6480464CTDValproic Acid affects the expression of MAP4K4 mRNAPMID:25979313
Map4k4decreases expressionISOMAP4K4 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of MAP4K4 mRNAPMID:23179753 PMID:27188386 PMID:29154799
Map4k4decreases methylationISOMAP4K4 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of MAP4K4 genePMID:29154799
Map4k4increases expressionISOMAP4K4 (Homo sapiens)6480464CTDValproic Acid results in increased expression of MAP4K4 mRNAPMID:26272509
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