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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305256
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrrn4
Name: leucine rich repeat neuronal 4
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrrn4affects methylationISOLRRN4 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of LRRN4 5' UTRPMID:27901495
Lrrn4decreases methylationISOLRRN4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of LRRN4 promoterPMID:27901495
Lrrn4decreases methylationISOLrrn4 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of LRRN4 intronPMID:27901495
Lrrn4increases expressionISOLRRN4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of LRRN4 mRNAPMID:20106945 PMID:21632981 PMID:21871943
Lrrn4multiple interactionsISOLrrn4 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to LRRN4 promoter]PMID:19654925
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