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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305241
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc39a1
Name: solute carrier family 39 member 1
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc39a1affects expressionISOSlc39a1 (Mus musculus)6480464CTDZinc affects the expression of SLC39A1 mRNAPMID:17085522
Slc39a1affects metabolic processingISOSlc39a1 (Mus musculus)6480464CTDSLC39A1 protein affects the metabolism of ZincPMID:16652366
Slc39a1decreases expressionISOSLC39A1 (Homo sapiens)6480464CTDZinc results in decreased expression of SLC39A1 mRNAPMID:15226459
Slc39a1increases transportISOSLC39A1 (Homo sapiens)6480464CTDSLC39A1 protein results in increased transport of ZincPMID:18326752
Slc39a1increases uptakeISOSLC39A1 (Homo sapiens)6480464CTDSLC39A1 protein results in increased uptake of ZincPMID:11301334 PMID:12888280
Slc39a1increases uptakeISOSlc39a1 (Mus musculus)6480464CTDSLC39A1 protein results in increased uptake of ZincPMID:14525987 PMID:15322118 PMID:25089007
Slc39a1multiple interactionsISOSLC39A1 (Homo sapiens)6480464CTDZinc deficiency promotes the reaction [ochratoxin A results in decreased expression of SLC39A1 mRNA]PMID:19720134
Slc39a1multiple interactionsISOSlc39a1 (Mus musculus)6480464CTDCadmium Chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]; cobaltous chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]; ferrous chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]; nickel chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]PMID:25089007
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