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GENE - TERM ANNOTATION REPORT

RGD ID: 1305069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad6
Name: SMAD family member 6
Acc ID: GO:0071144
Term: heteromeric SMAD protein complex
Definition: A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
Definition Source(s): GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad6part_ofIBAFB:FBgn0011648 or FB:FBgn0011655 or FB:FBgn0025800 or PANTHER:PTN000344419 or UniProtKB:P84022 or UniProtKB:Q13485 or UniProtKB:Q157961600115GO_CentralGO_REF:0000033

GO_REF:0000033
Smad6part_ofIBAFB:FBgn0011648 or FB:FBgn0011655 or FB:FBgn0025800 or PANTHER:PTN000344419 or UniProtKB:P84022 or UniProtKB:Q13485 or UniProtKB:Q15796 or UniProtKB:Q157971600115GO_CentralGO_REF:0000033

GO_REF:0000033
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