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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305066
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfsf18
Name: TNF superfamily member 18
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf18increases expressionISOTnfsf18 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of TNFSF18 proteinPMID:21951872
Tnfsf18increases response to substanceISOTnfsf18 (Mus musculus)6480464CTDTNFSF18 results in increased susceptibility to LipopolysaccharidesPMID:21951872
Tnfsf18multiple interactionsISOTnfsf18 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNFSF18 protein]; TNFSF18 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; TNFSF18 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:21951872
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