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GENE - TERM ANNOTATION REPORT

RGD ID: 1304988
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt10b
Name: Wnt family member 10B
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt10bacts_upstream_of_or_withinISOWnt10b (Mus musculus)1624291RGD MGI:3758508 PMID:10937998

MGI:3758508 PMID:10937998
Wnt10binvolved_inISOWNT10B (Homo sapiens)1624291RGD PMID:17761539

PMID:17761539
Wnt10binvolved_inIBAFB:FBgn0004360 or FB:FBgn0031902 or FB:FBgn0284084 or MGI:101948 or MGI:108061 or MGI:1197020 or MGI:1261834 or MGI:2446084 or MGI:98953 or MGI:98954 or MGI:98955 or MGI:98956 or MGI:98957 or MGI:98958 or MGI:98961 or MGI:98962 or PANTHER:PTN000246517 or Wnt7a (Rattus norvegicus) or UniProtKB:O00744 or UniProtKB:O00755 or UniProtKB:O14904 or UniProtKB:O14905 or UniProtKB:P04628 or UniProtKB:P09544 or UniProtKB:P56703 or UniProtKB:P56704 or UniProtKB:P56705 or UniProtKB:P56706 or UniProtKB:Q93097 or UniProtKB:Q93098 or UniProtKB:Q98SN7 or UniProtKB:Q9GZT5 or UniProtKB:Q9H1J5 or WB:WBGene00001188 or WB:WBGene00003395 or ZFIN:ZDB-GENE-980526-332 or ZFIN:ZDB-GENE-990415-2791600115GO_CentralGO_REF:0000033

GO_REF:0000033
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