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GENE - TERM ANNOTATION REPORT

RGD ID: 1304774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Castor1
Name: cytosolic arginine sensor for mTORC1 subunit 1
Acc ID: GO:0061700
Term: GATOR2 complex
Definition: A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.
Definition Source(s): GOC:krc, GOC:rb, PMID:23723238, PMID:25934700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Castor1located_inISOCASTOR1 (Homo sapiens)1624291RGD PMID:26972053

PMID:26972053
Castor1located_inISSUniProtKB:Q8WTX71600115UniProtGO_REF:0000024

GO_REF:0000024
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