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GENE - TERM ANNOTATION REPORT

RGD ID: 1304739
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Exosc3
Name: exosome component 3
Acc ID: GO:0000178
Term: exosome (RNase complex)
Definition: A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Definition Source(s): PMID:17174896, PMID:20531386, PMID:26726035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Exosc3part_ofISOEXOSC3 (Homo sapiens)1624291RGD PMID:20531389

PMID:20531389
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