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RGD ID: 1304738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ube4b
Name: ubiquitination factor E4B
Acc ID: GO:0034450
Term: ubiquitin-ubiquitin ligase activity
Definition: Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
Definition Source(s): GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.